Methods for reducing calcium deposits from bones & joints

I am researching calcifications in the body of horses because I have a horse that suffers from it. He has been put on Schuessler Salts but they will take a good while until they start to shift some of the conditions that had been there since a while.

I now found the following information for treatment on Patent of the US register which is from 1978. What it reads is very promising, so I will try to work out the formula and apply this remedy. It was developed to help horses in the racing industry back then.

An inert calcium deposit beneath the skin can be reduced by applying a mixture of dimethyl sulfoxide (DMSO) and papain, an enzyme from papaya, to the skin’s surface. DMSO helps carry the enzyme through the skin to the calcium deposit, where it gradually dissolves the calcium. The liquified calcium is then naturally removed from the body through its circulatory system.

DMSO penetrates the skin without affecting normal bodily functions, while the natural enzyme papain effectively breaks down the inert calcium deposits.

Aim of the invention

This innovation pertains to enhanced compositions and methods for reducing or ideally eliminating abnormal calcium deposits beneath the skin of animals or other living organisms. By liquefying or dissolving the calcium and utilizing the body’s natural circulatory process, these deposits can be removed from joints or tissue areas without the need for surgery or hypodermic injections, which could cause additional damage.

Racehorses often suffer from inert calcium spurs, lumps, or other deposits in their legs, leading to irritation, reduced mobility, and significant pain while running. These deposits severely limit the horse’s speed and typically shorten its racing career. Inert calcium deposits can similarly impact other animals and humans, where they contribute to arthritic conditions that cause painful and limiting reductions in mobility.


The goal of this invention is to offer a composition and treatment method that addresses the issues related to inert calcium deposits in animals and other organisms. This approach aims to reduce or completely eliminate abnormal calcium deposits from bones, joints, and other body areas, enhancing movement and reducing or eliminating pain with continued treatment.

The composition includes papain, an enzyme derived from Carica papaya, such as the commercially available “Papase” from Warner-Chilcott Laboratories. Papain does not affect bone calcium but effectively dissolves inert calcium. It also reduces swelling, promotes blood flow to affected areas, and supports the body’s natural circulatory processes.

Dimethyl sulfoxide (DMSO), with the chemical formula (CH3)2 SO, is the second key ingredient. DMSO, an organic compound derived from lignin found in wood, is a colorless liquid at room temperature. It penetrates living tissues and carries other substances through the skin.

Papain, typically available in a dry, solid form, is ground into a fine powder and thoroughly mixed with liquid DMSO to create a uniform composition. Additives such as Vitamin A may be included to aid healing, but the primary ingredients are papain and DMSO. The composition may solely consist of these two ingredients in some cases.

The mixture’s proportions range between approximately 200,000 and 1,000,000 Warner-Chilcott Units of papain per pint of DMSO. One Warner-Chilcott Unit represents the amount of proteolytic enzymes from Carica papaya that will clot 2.64 microliters of milk substrate in 2 minutes at 40°C. The final composition is a thin liquid, making it easy to apply directly to the skin, preferably by spraying.

Before applying the composition, it is advisable to thoroughly clean the skin with soap and water, rinse well, and allow it to air dry. For deposits located on the ankle or leg of a horse, or other animals with heavy hair, the hair can be clipped or brushed before cleaning and treating with the composition.

The affected area should be treated regularly, ideally at least once a day and preferably twice a day. During each application, enough of the liquid composition should be sprayed or applied to the skin to ensure it becomes reasonably wet. It is preferable not to bandage the area, leaving it exposed to the air as the composition dries and penetrates through the skin to reach the calcium deposit. This twice-daily treatment may continue for several days or weeks, typically around 10-12 weeks, leading to a gradual reduction and ideally complete removal of the calcium deposit over time.

Dimethyl sulfoxide (DMSO) helps transport the papain through the skin to the calcium deposit, where papain works to liquefy the calcium, progressively reducing its size. As the liquefied calcium is removed from joint areas, movement becomes less painful and more free. The removal of calcium from other areas similarly reduces pain associated with movement. This process is achieved without the need for surgical intervention or disturbing the skin’s natural protective barrier.

Examples of successfully treatments on several racehorses with calcium deposits

Example 1

A female thoroughbred racehorse developed calcium deposits in one of her front ankles, causing significant pain and impairing her racing performance. These deposits slowed her down and would have ended her racing career without intervention. Before treatment, noticeable lumps of calcium, approximately 3 to 5 millimeters in size, were felt on her anklebone and joint. This condition is often referred to as a “bowed” ankle.

The treatment composition used consisted solely of papain and dimethyl sulfoxide (DMSO) mixed into a uniform liquid. The papain was sourced from the product “Papase” by Warner-Chilcott Laboratories, known for its proteolytic enzymes from Carica papaya. The DMSO was obtained from Mallinckrodt, Inc. of St. Louis, Missouri. The mixture was prepared in the proportion of 300,000 Warner-Chilcott Units of enzymes per pint of DMSO.

The horse underwent treatment twice daily, morning and evening, for 12 weeks. Initially, the hair around the affected ankle was clipped. Each treatment session began with brushing and thoroughly washing the skin with soap and water, followed by rinsing and air drying. The composition was then sprayed onto the ankle at the site of the calcium deposits, ensuring the area appeared reasonably wet. The ankle was left uncovered to dry naturally.

Throughout the treatment period, the lumps gradually diminished in size, and after 12 weeks, they had completely disappeared. The horse no longer exhibited signs of pain and was able to run and race more effectively than before the treatment.

Example 2

A quarter horse stud in the roping class had a completely immobilized left front ankle, showing no capacity for movement and evident severe pain. Through the skin, abnormal calcium deposits felt almost solid at the ankle joint, causing noticeable swelling and a misshapen appearance that was visibly different from the right ankle.

The same composition described in the first example, consisting of 300,000 Warner-Chilcott Units of papain per pint of dimethyl sulfoxide (DMSO), was applied twice daily, morning and evening, for six weeks. The treatment procedure followed was identical to that in the first example. After this period, the previously immobile left front ankle regained substantial mobility. The horse no longer stumbled as it did before the treatment, and the ankle’s size visibly and significantly reduced. Initially, the horse was in such poor condition that it could only be worked about one day in four. However, after six weeks of treatment, the horse could be worked every day without any signs of pain or difficulty.

Example 3

A female thoroughbred horse suffered from “shin buck,” a condition where minute calcium deposits formed in the thin layer of skin at the front of the leg, causing extreme pain. This pain was evident from the horse’s reactions after exercise and when moving its legs, rendering it unable to run.

The treatment composition for this horse included 500,000 Warner-Chilcott Units of papain (from the product “Papase” by Warner-Chilcott Laboratories) per pint of dimethyl sulfoxide (DMSO), along with 200,000 units of injectable Vitamin A to aid healing. The horse received this treatment twice daily, in the morning and evening, for two weeks. Initially, the hair on the affected leg was clipped, and each treatment session followed a procedure of washing, rinsing, and air drying the area.

At the end of the two-week treatment period, the horse showed no signs of soreness and could walk and run without any pain, effectively curing the “shin buck.”

Example 4

A horse in this example had developed a calcium spur on one ankle, which was visible in an X-ray of the ankle. The spur had broken off from the original bone. The composition described in Example 3 was sprayed onto the skin of the ankle, opposite the spur, twice a day, morning and night, for 12 weeks. Following this treatment period, X-ray examination revealed that the spur had completely disappeared. The clipping and cleaning procedures were, of course, followed in this example as in the other cases described above.

After the treatment, the horse, previously in great pain and completely unable to race, was once again able to race and even won at least one race of which I am aware.


While certain specific embodiments of the present invention have been disclosed as typical, it’s important to note that the invention is not limited to these particular forms. Instead, it is broadly applicable to all such variations that fall within the scope of the appended claims.